Biosynthesis of trichothecene mycotoxins in Fusarium culmorum cultures.

نویسندگان

  • N C Baldwin
  • B W Bycroft
  • P M Dewick
  • J Gilbert
  • I Holden
چکیده

A high yielding production of the trichothecene mycotoxin 3-acetyldeoxynivalenol (3-AcDON) in cultures of Fusarium culmorum is described. By supplying [14C]acetate, 14C-labelled 3-AcDON suitable for further metabolic studies has been obtained. The pattern of labelling has been ascertained by using 13C-labelled acetate precursors, and is in line with established biosynthetic data. A second trichothecene produced in significant amounts by F. culmorum has been identified as 3 alpha, 15-diacetoxy-7 alpha, 8 alpha-dihydroxy-12, 13-epoxytrichothec-9-ene (7 alpha, 8 alpha-dihydroxycalonectrin).

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Trichothecene mycotoxins from Fusarium culmorum cultures.

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عنوان ژورنال:
  • Zeitschrift fur Naturforschung. Section C, Biosciences

دوره 40 7-8  شماره 

صفحات  -

تاریخ انتشار 1985